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    Evolutionary Biology

Metagenomic Analysis Reveals Presence of Treponema denticola in a Tissue Biopsy of the Iceman

Abstract Ancient hominoid genome studies can be regarded by definition as metagenomic analyses since they represent a mixture of both hominoid and microbial sequences in an environment. Here, we report the molecular detection of the oral spirochete Treponema denticola in ancient human tissue biopsies of the Iceman, a 5,300-year-old Copper Age natural ice mummy.

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