Mechanical stimulation improves tissue-engineered skeletal muscle

Human bioartificial muscles (HBAMs) are tissue engineered by suspending muscle cells in collagen/MATRIGEL, casting in a silicone mold containing end attachment sites, and allowing the cells to differentiate for 8 to 16 days. The resulting HBAMs are representative of skeletal muscle in that they contain parallel arrays of postmitotic myofibers; however, they differ in many other morphological characteristics.

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This article talks about the use of bioartificial muscles that are mechanically made to mimic muscles and the muscle fibers by engineering tissue.  This relates to class material because we have been talking about the different forces... more »This article talks about the use of bioartificial muscles that are mechanically made to mimic muscles and the muscle fibers by engineering tissue.  This relates to class material because we have been talking about the different forces acting on the human body, so this article takes engineered tissue and added mechanical forces to improve HBAMs morphology.  As of right now, the HBAMs have limited resemblance to adult skeletal muscle, but there are still some myofibril relationships and this is just the start.  Further improvements may be possible by changing mechanical stimulation to interact more with the hormones, nutrition, and exercise involved with muscular tissue development, which are the necessary structural and functional characteristics for repair or replacement of skeletal muscle.  In the end, if we can master this skill, we will be able to help prevent muscle deterioration associated with age, disease, or injury. 09-23-2016 12:12pm

Comment by Riley Evans

    Added to this shelf by: Riley Evans , on 09-23-2016 12:12pm

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